學 術 報 告

　　報告題目： Single Cell Gene Therapy and Analysis on Nano-electroporation Chip

　　報告人：常凌乾

　　北京航空航天大學 生物與醫院工程學院，教授

　　主持人：蔣嵐 研究員

　　時 間：2019年4月23日（星期二）下午14:00-15:30

　　地 點：中國科學院北京基因組研究所一層報告廳

　　報告人簡介：

　　常凌乾博士，2016年博士畢業于美國俄亥俄州立大學生物醫學工程系，現為北京航空航天大學生物與醫學工程學院和醫工交叉高精尖中心單細胞分析納米技術研究所教授。曾擔任美國北德克薩斯大學(University of North Texas)生物醫學工程系助理教授。 常凌乾博士的研究方向：單細胞基因轉染技術和細胞微操縱技術及其在細胞基因檢測、治療等領域的研究。近五年在國際期刊發表SCI論文50篇，如Nature Nanotechnology, Nano Letters, Small等。申請或授權美國專利3項，中國專利3項。獲得了諸多科研獎勵和榮譽，如俄亥俄州立大學2015年博士最高獎Presidential Fellowship，北德克薩斯大學RSG Awards, MINE 2018‘杰出青年科學家’提名獎等。兼任SCI期刊Biomedical Engineering Online副主編（Associate Editor）和Computers in Biology and Medicine編委(Editorial Board)，Nature Springer《Electroporation Protocol》第三版主編，中國生物醫學工程學會納米醫藥分會青年委員。

　　Abstract:

　　One of the cutting-edge multidisciplinary research themes in Biomedical Engineering is to design and manufacture advanced Bio-Chip for life science, ranging from in vitro cell biology toward in vivo medicine. In recent years, nanotechnologies facilitate the development of bio-chips and devices which have demonstrated unprecedented capabilities in single cell analysis and manipulation. In this talk, a novel nano-biotechnology, nano-electroporation (NEP), is introduced with emphasis on high-throughput, and precisely delivery of gene / drugs into living cells at single-cell resolution.

　　The in vitro applications of the NEP platform have been demonstrated in the studies of intracellular cancer biomarker heterogeneity in leukemic cells, cardiomyocytes, T lymphocytes and glioma stem cells. Our latest efforts have achieved in vivo cell reprogramming for on-body gene therapy and wound healing. The future research of this nano-technique for flexible wearable drug delivery platform with the aims to patient-specific gene therapy and regenerative medicine are discussed.

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