侯婭麗----中國科學院北京基因組研究所

簡介
研究方向
發表論著
承擔科研項目
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侯婭麗(Yali Hou)

碩士生導師，副研究員,青促會

E-Mail：houyl@big.ac.cn

研究領域：遺傳學基因組學生物信息學

導師簡介：

學習經歷：

2005年9月-2009年2月：中國農業大學博士學位

1998年9月-2005年7月：山西農業大學學士學位碩士學位

工作經歷：

2006年10月–2008年2月丹麥奧胡斯大學遺傳與生物技術系訪問學者

2009年9月–2012年1月美國馬里蘭大學農業與自然資源院動物和鳥類科學系博士后

（其間：2009年10月–2012年1月美國農業部農業研究所動物與自然資源系訪問學者）

2012年2月–至今中國科學院北京基因組研究所中國科學院精準基因組醫學重點實驗室副研究員

學術兼職：
Genomics, Proteomics & Bioinformatics Junior editor (2023- )
The Farm animal Genotype-Tissue Expression (FarmGTEx) Consortium member (2022- )
Cell Evolution Junior editor (2022- )
Frontier in Genetics Review editor (2019- )
遺傳學會, 會員（2015-）

獲獎及榮譽：

2015年中國科學院青年創新促進會

近期主要學術成果：

1.Yali Hou#, Shilei Zhao#, Qi Liu#, Xiaolong Zhang#, Tong Sha, Yankai Su, Wenming Zhao, Yiming Bao, Yongbiao Xue, Hua Chen, Ongoing positive selection drives the evolution of SARS-CoV-2 genomes, Genomics, Proteomics & Bioinformatics, 2022, 10.1016/j.gpb.2022.05.009.

2.Shilei Zhao#, Yali Hou#, Xiaolong Zhang#, Alice Hughes, Na Liu, Minsheng Peng, Qihui Wang, Yongbiao Xue, Hua Chen, pinpointing the animal origins of SARS-CoV-2: a genomic approach, Journal of Genetics and Genomics, 2022, S1673-8527(22)00153-9.

3.Xia Chen#, Xue Bai#, Huagui Liu, Binbin Zhao, Zhixun Yan, Yali Hou*, Qin Chu*, Population genomic sequencing delineates global landscape of copy number variations that drive domestication and breed formation in Chicken, Frontiers in Genetics, 2022, 13:830393.

4.Chunyan Li#, Melisa Olave#, Yali Hou#, Geng Qin#, Ralf F. Schneider#, Zexia Gao#, Xiaolong Tu, Xin Wang, Furong Qi, Alexander Nater, Andreas F. Kautt, Shiming Wan, Yanhong Zhang, Yali Liu, Huixian Zhang, Bo Zhang, Hao Zhang, Meng Qu, Shuaishuai Liu, Zeyu Chen, Jia Zhong, He Zhang, Lingfeng Meng, Kai Wang, Jianping Yin, Liangmin Huang, Byrappa Venkatesh, Axel Meyer*, Xuemei Lu*, and Qiang Lin*, Genome sequences reveal global dispersal routes and suggest convergent genetic adaptations in seahorse evolution, Nature Communication, 2021, 12: https://doi.org/10.1038/s41467-021-21379-x.

5.Yali Hou#, Yan Xie#, Shaohua Yang#, Bo Han, Lijun Shi, Xue Bai, Ruobing Liang, Tian Dong, Shengli Zhang, Qin Zhang, Dongxiao Sun*, EEF1D facilitates milk lipid synthesis by regulation of PI3K-Akt signaling in mammals, The FASEB Journal, 2021, 35(5):e21455.

6.Yali Hou#*, Furong Qi#, Xue Bai#, Tong Ren, Xu Shen, Qin Chu, Xiquan Zhang*, Xuemei Lu*, Genome-wide analysis reveals molecular convergence underlying domestication in 7 bird and mammals, BMC Genomics, 2020, 21(1): 204.

7.Chunyan Li#, Yali Hou#, Jin Xu#, Aiqun Zhang, Zhenzhen Liu, Furong Qi, Zuyu Yang, Ke Chen, Sixue Liu, Huanwei Huang, Qianfei Wang, Jiahong Dong, Chung-I Wu, Xuemei Lu*, A direct test of selection in cell populations using the diversity in gene expression within tumors, Molecular Biology and Evolution, 2017, 34(7): 1730-1742.

8.Derek M. Bickhart#, Yali Hou#, Steven G. Schroeder, Can Alkan, Maria Francesca Cardone, Lakshmi K. Matukumalli, Jiuzhou Song, Robert D. Schnabel, Mario Ventura, Jeremy F. Taylor, Jose Fernando Garcia, Curtis P. Van Tassell, Tad S. Sonstegard, Evan E. Eichler, George E. Liu*, Copy number variation of individual cattle genomes using next-generation sequencing, Genome Research, 2012, 22(4): 778-790.

9.Furong Qi, Airong Yang, Sadaf Ambreen, Xue Bai, Yali Hou*, Xuemei Lu*, Birth and death of Mx genes and the presence/absence of genes regulating Mx transcription are correlated with the diversity of anti-pathogenicity in vertebrate species, Molecular genetics and genomics, 2019, 294(1): 121-133.

10.Lingyang Xu#, Yali Hou#, Derek M. Bickhart, Yang Zhou, El Hamidi abdel Hay, Jiuzhou Song, Tad S. Sonstegard, Curtis P. Van Tassell, George E. Liu*, Population-genetic properties of differentiated copy number variations in cattle, Scientific reports, 2016, 6: 23161.

11.Lingzhao Fang#, Yali Hou#, Jing An, Bingjie Li, Minyan Song, Xiao Wang, Peter S?rensen, Yichun Dong, Chao Liu, Yachun Wang, Huabin Zhu, Shengli Zhang, Ying Yu*, Genome-wide transcriptional and post-transcriptional regulation of innate immune and defense responses of bovine mammary gland to Staphylococcus aureus, Frontiers in Cellular and Infection Microbiology, 2016, 6: 193.

12.Kaile Wang, Qin Ma, Lan Jiang, Shujuan Lai, Xuemei Lu, Yali Hou*, Chung-I Wu*, Jue Ruan*, Ultra-precise detection of mutations by droplet-based amplification of circularized DNA, BMC Genomics, 2016, 17: 214.

13.Fan H#, Hou Y#, Sahana G, Gao H, Zhu C, Du L, Zhao F, Wang L, A transcriptomic study of the tail fat deposition in two types of Hulun Buir Sheep according to tail size and sex, Animals, 2019, 9(9): 655.

14.Gang Guo, Yali Hou*, Yuan Zhang, Guosheng Su*. Comparison of models for genetic evaluation of number of inseminations to conception in Danish Holstein cows: GENETIC EVALUATION OF NUMBER OF INSEMINATIONS, 2016, Animal Science Journal, 88(4): 567-574.

15.Xiaogang Cui#, Yali Hou#, Shaohua Yang, Yan Xie, Shengli Zhang, Yuan Zhang, Qin Zhang, Xuemei Lu, George E. Liu, Dongxiao Sun*, Transcriptional profiling of mammary gland in Holstein cows with extremely different milk protein and fat percentage using RNA sequencing, BMC Genomics, 2014, 15: 226.

16.Yali Hou#, Yachun Wang#, Xuemei Lu#, Xu Zhang, Qian Zhao, Rory J. Todhunter*, Zhiwu Zhang*, Monitoring hip and elbow dysplasia achieved modest genetic improvement of 74 dog breeds over 40 years in USA, PLoS One, 2013, 8(10): e76390.

17.Yali Hou, Derek M. Bickhart, Hvinden ML, Li C, Jiuzhou Song, Boichard DA, Fritz S, Eggen A, DeNise S, Wiggans GR, Tad S. Sonstegard, Curtis P. Van Tassell, George E. Liu *. Fine mapping of copy number variations on two cattle genome assemblies using high density SNP array. BMC Genomics, 2012, 13: 376.

18.Yali Hou, Derek M. Bickhart, Hoyoung Chung, Jana L. Hutchison, H. Duane Norman, Erin E. Connor*, George E. Liu*, Analyses of copy number variations in Holstein cows identify potential mechanisms contributing to differences in residual feed intake, Functional & Integrative Genomics, 2012, 12(4): 717-723.

19.Yali Hou, George E. Liu*, Derek M. Bickhart, Lakshmi K. Matukumalli, Congjun Li, Jiuzhou Song, Louis C. Gasbarre, Curtis P. Van Tassell, Tad S. Sonstegard, Genomic regions showing copy number variations associate with resistance or susceptibility to gastrointestinal nematodes in Angus cattle, Functional & Integrative Genomics, 2012, 12(1): 81-92.

20.Yali Hou, George E. Liu*, Derek M. Bickhart, Maria Francesca Cardone, Kai Wang, Eui-soo Kim, Lakshmi K. Matukumalli, Mario Ventura, Jiuzhou Song, Paul M. VanRaden, Tad S. Sonstegard, Curtis P. Van Tassell, Genomic characteristics of cattle copy number variations, BMC Genomics, 2011, 12: 127.

21.Yali Hou#, Yachun Wang#, George Lust, Lan Zhu, Zhiwu Zhang*, Rory J. Todhunter, Retrospective analysis for genetic improvement of hip joints of cohort labrador retrievers in the United States: 1970-2007, PLoS One, 2010, 5(2): e9410.

22.Yali Hou, Per Madsen, Rodrigo Labouriau, Yuan Zhang, Mogens Sand? Lund, Guosheng Su*, Genetic analysis of days from calving to first insemination and days open in Danish Holsteins using different models and censoring scenarios, J Dairy Sci., 2009, 92(3): 1229-1239.

23.Dong Liang #, Pengju Zhao #, Jingfang Si, Lingzhao Fang, Erola Pairo-Castineira, Xiaoxiang Hu, Qing Xu, Yali Hou, Yu Gong, Zhengwen Liang, Bing Tian, Huaming Mao, Marnoch Yindee, Md Omar Faruque, Siton Kongvongxay, Souksamlane Khamphoumee, George E. Liu, Dong-Dong Wu, James Stuart F. Barker, Jianlin Han,* and Yi Zhang*, Genomic analysis revealed a convergent evolution of LINE-1 in coat color: A case study in water buffaloes (Bubalus bubalis), Molecular Biology and Evolution, 38(3):1122–1136.

24.Tao Li #, Jialin Liu #, Jing Feng #, Zhenzhen Liu, Sixue Liu, Minjie Zhang, Yuezheng Zhang, Yali Hou, Dafei Wu, Chunyan Li, Yongbin Chen, Hua Chen, Xuemei Lu, Variation in the life history strategy underlies functional diversity of tumors, National Science Review, 2021, 8(2): nwaa124.

25.Shan Lin, Hongyan Zhang, Yali Hou, Lin Liu, Wenhui Li, Jianping Jiang, Bo Han, Shengli Zhang, Dongxiao Sun*, SNV discovery and functional candidate gene identification for milk composition based on whole genome resequencing of Holstein bulls with extremely high and low breeding values, 2019, PLoS One, 14(8):e0220629.

26.Yahui Gao, Jianping Jiang, Shaohua Yang, Yali Hou, George E Liu, Shengli Zhang, Qin Zhang, Dongxiao Sun, CNV discovery for milk composition traits in dairy cattle using whole genome resequencing, BMC Genomics, 2017,18, 265.

27.Jianping Jiang, Yahui Gao, Yali Hou, Wenhui Li, Shengli Zhang, Qin Zhang, Dongxiao Sun*, Whole-Genome Resequencing of Holstein Bulls for Indel Discovery and Identification of Genes Associated with Milk Composition Traits in Dairy Cattle, 2016, PLoS One, 11(12): e0168946.

28.Xu L, Cole JB, Bickhart DM, Hou Y, Song J, VanRaden PM, Sonstegard TS, Van Tassell CP, Liu GE*, Genome wide CNV analysis reveals additional variants associated with milk production traits in Holsteins, BMC Genomics, 2014, 15:683.

29.Xu L, Hou Y, Bickhart DM, Song J, Van Tassell CP, Sonstegard TS, Liu GE*, A genome-wide survey reveals a deletion polymorphism associated with resistance to gastrointestinal nematodes in Angus cattle, Functional & Integrative Genomics, 2014，14(2): 333-339.

30.George E. Liu*, Yali Hou, Bin Zhu, Maria Francesca Cardone, Lu Jiang, Angelo Cellamare, Apratim Mitra, Leeson J. Alexander, Luiz L. Coutinho, Maria Elena Dell'Aquila, Lou C. Gasbarre, Gianni Lacalandra, Robert W. Li, Lakshmi K. Matukumalli, Dan Nonneman, Luciana C. de A. Regitano, Tim P.L. Smith, Jiuzhou Song, Tad S. Sonstegard, Curtis P. Van Tassell, Mario Ventura, Evan E. Eichler, Tara G. McDaneld, John W. Keele*, Analysis of copy number variations among diverse cattle breeds, Genome Research, 2010, 20(5): 693-703.