- 簡介
- 研究方向
- 發表論著
- 承擔科研項目
- 項目組情況
- 招生信息

學習經歷:
1988年9月-1993年7月,山東醫科大學,臨床醫學專業,醫學學士學位
1997年9月-2002年2月,美國約翰霍普金斯大學,遺傳流行病學專業,博士學位
工作經歷:
2015年1月-至今 中國科學院北京基因組研究所 研究員 博士生導師
2007年1月-2015年1月 美國西北大學 兒科系助理教授
2004年2月-2006年12月 美國加州大學舊金山分校 遺傳流行病學專業博士后
2002年2月-2003年12月 美國約翰霍普金斯大學布隆博格公共衛生學院 遺傳流行病學專業博士后
1993年9月-1995年11月 北京工人療養院 內科醫生
學術兼職:
獲獎及榮譽:
人類復雜疾病的遺傳和表觀遺傳研究
近期主要學術成果:
代表論著(*: corresponding author): 1. PDGFRB mutation and tyrosine kinase inhibitor resistance in Ph-like acute lymphoblastic leukemia. 2. Genome-wide association study of maternal genetic effects and parent-of-origin effects on food allergy. 3. Genome-wide approach identifies a novel gene-maternal pre-pregnancy BMI interaction on preterm birth. 4. Genome-wide DNA Methylation Associations with Spontaneous Preterm Birth in US Blacks: Findings in Maternal and Cord Blood Samples. Epigenetics. (Epub ahead of print) 5. Racial Disparity in the Associations of Cotinine with Insulin Secretion: Data from the National Health and Nutrition Examination Survey, 2007-2012. 6. Genome-wide Association Study of Food Allergy Identifies Peanut Allergy-Specific Susceptibility Loci and Evidence of Epigenetic Mediation in U.S. Children of European Ancestry. 7. Maternal Pre-conception Body Mass Index and Offspring Cord Blood DNA Methylation: Exploration of Early Life Origins of Disease. 8. Blood methylomics in response to arsenic exposure in a low-exposed US population. 9. Longitudinal trajectory of vitamin D status from birth to early childhood in the development of food sensitization. 10. Microsomal epoxide hydrolase (EPHX1) polymorphisms are associated with aberrant promoter methylation of ERCC3 and hematotoxicity in benzene-exposed workers. 11. Individual variation and longitudinal pattern of genome-wide DNA methylation from birth to the first two years of life. 12. Associations between gene polymorphisms in fatty acid metabolism pathway and preterm delivery in a U.S. urban black population. 13. A population-based twin study on sleep duration and body composition. 14.Association between short sleep duration and the risk of sensitization to food and aero allergens in Rural Chinese Adolescents. 15. Fine mapping of prostate cancer aggressiveness loci on chromosome 7q22-35. 16. Gene-Vitamin D interactions on food sensitization: a prospective birth cohort study. 17. Genetic and Environmental Contributions to Allergen Sensitization in a Chinese Twin Study. 18. Trans Fatty Acid Intake and Increased Risk of Advanced Prostate Cancer: Modification by RNASEL R462Q Variant. 19. Multiple Essential Hypertension Susceptibility Genes On Chromosome 1q. 20. Nonsteroidal Anti-inflammatory Drugs and Decreased Risk of Advanced Prostate Cancer: Modification by Lymphotoxin Alpha. 21. Hierarchical modeling in association studies of multiple phenotypes. 22. Genetic dissection methods: designs used for tests of gene-environment interaction. 23. Associations between specific serum IgE response and 6 variants within the genes IL4, IL13, and IL4RA in German children: the German Multicenter Atopy Study.
Blood. 131(20):2256-2261,2018
Zhang Y, Gao Y, Zhang H, Zhang J, He F, Hnízda A, Qian M, Liu X, Gocho Y, Pui CH, Cheng T, Wang Q, Yang JJ*, Zhu X*, Liu X*.
Medicine. 97(9):e0043,2018
Liu X*, Hong X, Tsai HJ, Mestan KK, Shi M, Kefi A, Hao K, Chen Q, Wang G, Caruso D, Geng H, Gao Y, He J, Kumar R, Wang H, Yu Y, Bartell T, Tan XD, Schleimer RP, Weeks DE, Pongracic JA, Wang X.
Nat Commun. 8:15608, 2017
Hong X, Hao K, Ji H, Peng S, Sherwood B, Di Narzo A, Tsai HJ, Liu X, Burd I, Wang G, Ji Y, Caruso D, Mao G, Bartell TR, Zhang Z, Pearson C, Heffner L, Cerda S, Beaty TH, Fallin MD, Lee-Parritz A, Zuckerman B, Weeks DE, Wang X.
Hong X, Sherwood B, Ladd-Acosta C, Peng S, Ji H, Hao K, Burd I, Bartell TR, Wang G, Tsai HJ, Liu X, Ji Y, Wahl A, Caruso D, Lee-Parritz A, Zuckerman B, Wang X.
Plos One. 11(12):e0167260, 2016
Liu R*, Zheng Z, Du J, Christoffel KK, Liu X*.
Nat Commun. 24;6:6304, 2015
Hong X, Hao K, Ladd-Acosta C, Hansen KD, Tsai HJ, Liu X, Xu X, Thornton TA, Caruso D, Keet CA, Sun Y, Wang G, Luo W, Kumar R, Fuleihan R, Singh AM, Kim JS, Story RE, Gupta RS, Gao P, Chen Z, Walker SO, Bartell TR, Beaty TH, Fallin MD, Schleimer R, Holt PG, Nadeau KC, Wood RA, Pongracic JA, Weeks DE, Wang X.
Environ Mol Mutagen. 55(3):223-30, 2014
Liu X*, Chen Q, Tsai HJ, Wang GY, Hong XM, Zhou Y, Zhang CL, Liu CY, Liu R, Wang HJ, Zhang SC, Yu YX, Mestan K, Pearson P, Otlans P, Zuckerman P, Wang XB.
J Expo Sci Environ Epidemiol. 24(2):145-9, 2014
Liu X, Zheng YN, Zhang W, Zhang X, LIoyd-Jones DM, Baccarelli AA, Ning HY, Fornage M, He K, Liu K, Hou LF.
Pediatr Res. 74(3):321-6, 2013
Liu X*, Arguelles L, Zhou Y, Wang GY, Chen Q, Tsai HJ, Hong XM, Liu R, Price HE, Pearson C, Apollon S, Cruz N, Schleimer R, Langman CB, Pongracic J, Wang XB.
Environ Mol Mutagen. 54(6): 397-405, 2013
Xing CH, Chen Q, Li GL, Zhang LY, Zheng M, Zou ZY, Hou LF, Wang QF, Liu X*, Guo XB*.
Epigenetics. 7(6): 594-605, 2012
Wang D*, Liu X*, Zhou Y, Xie H, Hong XM, Tsai HJ, Wang GY, Liu R, Wang XB.
Hum Genet. 131(3):341-51, 2012
Liu X*, Wang GY, Hong XM, Tsai HJ, Liu R, Zhang SC, Wang HJ, Pearson C, Ortiz K, Wang D, Hirsch E, Zuckerman B, Wang XB.
Obesity. 20(1):192-9, 2012
Liu R, Liu X, Arguelles L, Patwari, PP, Zee PC, Chervin RD, Ouyang F, Christoffel KK, Zhang SC, Wang GY, Xu X, Wang XB.
Clin Exp Allergy. 41(4):547-55, 2011
Zhang S, Liu X (Co-first author), Kim JS, Ouyang F, Wang B, Li Z, Tang G, Liu X, Yang J, Xu X, Pongracic JA, Wang X.
Prostate. 71(7): 682-685, 2011
Liu X, Cheng I, Plummer SJ, Suarez B, Casey G, Catalona WJ, Witte JS.
Allergy. 66(11):1442-8, 2011
Liu X*, Wang GY, Hong XM, Wang D, Tsai HJ, Zhang SC, Arguelles L, Kumar R, Wang HJ, Liu R, Zhou Y, Pearson C, Ortiz K, Schleimer R, Holt P, Pongracic J, Price HE, Langman C, Wang XB.
Clin Exp Allergy. 39(7):991-8, 2009
Liu X*, Zhang SC, Tsai HJ, Hong XM, Wang BY, Fang YP, Liu X, Pongracic J, Wang X.
Carcinogenesis. 28:1232-6, 2007
Liu X*, Schumacher FR, Plummer SJ, Jorgenson E, Casey G, Witte JS*.
Am J Hum Genet. 80: 253-264, 2007
Chang YP, Liu X, Kim J, Ikeda MA, Layton M, Weder A, Cooper R, Kardia S, Rao DC, Hunt S, Luke A, Boerwinkle E, Chakravarti A.
Am J Epidemiol. 164:984-989, 2006
Liu X, Plummer SJ, Nock NL, Casey G, Witte JS.
BMC Genet. 6(S1):S104, 2005
Liu X, Jorgenson E, Witte JS.
Curr Opin Genet Dev. 14:241-245, 2004
Liu X, Fallin MD, Kao WH.
J Allergy Clin Immunol. 113:489-95, 2004
Liu X, Beaty TH, Deindl P, Huang SK, Lau S, Sommerfeld C, Fallin D, Kao WH, Wahn U, Nickel R.
1.國家自然科學基金面上項目,兒童噬血細胞綜合征的遺傳突變研究,2016-2019,在研,項目負責人;
2.中科院重點部署,中國人群精準醫學研究計劃/職業人群隊列建立及精準醫學研究, 2015-2018,在研,項目負責人。
項目組簡介:
復雜性狀和疾病(例如,體脂百分比、血脂、糖尿病、惡性腫瘤等)是諸多遺傳和非遺傳因素以及他們之間長期相互作用的結果。但是目前對于這些復雜表型決定因素的認知有限,從而阻礙了疾病的早期精準預測和治療。研究組將在自然人群、臨床患者和疾病家系中進行基因組和表觀基因組等組學的分析,發現導致疾病發生、影響藥物敏感性的遺傳和表觀遺傳變異等分子標記物,探索基因和環境相互作用與復雜性狀/疾病風險的關聯性。為疾病易感人群的發現和疾病早期診斷、預防和治療提供理論依據, 從而為最終實現精準醫療奠定基礎。
研究組目前的主要研究工作:
1.中科院人群隊列建立及精準醫學研究
2.兒童噬血細胞綜合征的遺傳突變研究
3.家族性多發腫瘤的遺傳變異研究
4.家族性嗜酸性粒細胞增多癥的遺傳變異研究
5. 白血病藥物治療的遺傳及表觀遺傳機制的研究
臨床合作單位:
中國醫學科學院天津血液病醫院
首都醫科大學附屬北京兒童醫院
福建醫科大學附屬協和醫院
南京醫科大學第一附屬醫院
華中科技大學附屬同濟醫院
招收臨床醫學、生物信息學、生物統計學專業背景的學生。 |